Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study
Por:
Chaparro, M, Garre, A, Ortiz, A, Palomares, M, Rodriguez, C, Riestra, S, Vela, M, Benitez, J, Salgado, E, Rodriguez, E, Hernandez, V, Ferreiro-Iglesias, R, Diaz, A, Barrio, J, Huguet, J, Sicilia, B, Martin-Arranz, M, Calvet, X, Ginard, D, Alonso-Abreu, I, Fernandez-Salazar, L, Trastoy, P, Rivero, M, Vera-Mendoza, I, Vega, P, Navarro, P, Sierra, M, Cabriada, J, Aguas, M, Vicente, R, Navarro-Llavat, M, Echarri, A, Gomollon, F, del Rio, E, Pinero, C, Casanova, M, Spicakova, K, de Zarate, J, Cortes, E, Gutierrez, A, Alonso-Galan, H, Hernandez-Martinez, A, Marrero, J, Poyatos, R, Calafat, M, Romero, L, Robledo, P, Bosch, O, Jimenez, N, Comas, M, Duque, J, Coronel, A, Sampedro, M, Abizanda, E, Martinez, B, Pozzati, L, Rosaenz, H, Suarez, B, Serrano, P, Lucendo, A, Vicente, M, Bermejo, F, Palanca, J, Menacho, M, Carmona, A, Camargo, R, Alsina, S, Maroto, N, de la Puerta, J, Castro, E, Marin-Jimenez, I, Botella, B, Sapina, A, Cruz, N, Forcelledo, J, Bouhmidi, A, Castano-Milla, C, Opio, V, Nicolas, I, Kutz, M, Bechiarelli, A, Gordillo, J, Ber, Y, Dominguez, Y, Duran, M, Mondejar, S, Martinez-Cerezo, F, Kolle, L, Sabat, M, Ledezma, C, Iyo, E, Roncero, O, Irisarri, R, Lluis, L, Gomez, I, Zapata, E, Alcala, M, Pascual, C, Montealegre, M, Mata, L, Monrobel, A, Camba, A, Hernandez, L, Tejada, M, Mir, A, Galve, M, Soler, M, Hervias, D, Gomez-Valero, J, Barreiro-de Acosta, M, Rodriguez-Artalejo, F, Garcia-Esquinas, E and Gisbert, J
Publicada:
1 jul 2021
Ahead of Print:
29 jun 2021
Categoría:
Medicine (miscellaneous)
Resumen:
(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery.
Filiaciones:
Chaparro, M:
Univ Autonoma Madrid, Hosp Univ La Princesa, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Inst Invest Sanitaria La Princesa IIS IP, Madrid 28006, Spain
Garre, A:
Univ Autonoma Madrid, Hosp Univ La Princesa, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Inst Invest Sanitaria La Princesa IIS IP, Madrid 28006, Spain
Ortiz, A:
Hosp Univ Virgen del Rocio, Dept Gastroenterol, Seville 41013, Spain
Palomares, M:
Hosp Univ A Coruna, Dept Gastroenterol, La Coruna 15006, Spain
Rodriguez, C:
Complejo Hosp Navarra, Dept Gastroenterol, Pamplona 31008, Spain
Riestra, S:
Hosp Univ Cent Asturias, Dept Gastroenterol, Oviedo 33011, Spain
ISPA, Oviedo 33011, Spain
Vela, M:
Complejo Hosp Univ Ntra Sra de Candelaria, Dept Gastroenterol, Santa Cruz De Tenerife 38010, Spain
Benitez, J:
Hosp Univ Reina Sofia, Dept Gastroenterol, Cordoba 14004, Spain
IMIBIC, Cordoba 14004, Spain
Salgado, E:
Complexo Hosp Univ Pontevedra, Inst Invest Sanitaria Galicia Sur, Dept Gastroenterol, Pontevedra 36071, Spain
Rodriguez, E:
Hosp Ramon & Cajal, Dept Gastroenterol, Madrid 28034, Spain
Hernandez, V:
Hosp Alvaro Cunqueiro, Dept Gastroenterol, Estrutura Org Xest Integrada Vigo, Vigo 36213, Spain
Ferreiro-Iglesias, R:
Complexo Hosp Univ Santiago, Dept Gastroenterol, Santiago De Compostela 15706, Spain
Diaz, A:
Hosp Univ Infanta Leonor, Dept Gastroenterol, Madrid 28031, Spain
Barrio, J:
Hosp Univ Rio Hortega, Dept Gastroenterol, Valladolid 47012, Spain
Huguet, J:
Consorcio Hosp Gen Univ Valencia, Dept Gastroenterol, Valencia 46014, Spain
Sicilia, B:
Hosp Univ Burgos, Dept Gastroenterol, Burgos 09006, Spain
Martin-Arranz, M:
Hosp Univ La Paz, Dept Gastroenterol, Madrid 28046, Spain
Calvet, X:
Univ Autonoma Barcelona, Serv Malalties Digest, Hosp Sabadell, Inst Univ Parc Tauli,CIBEREHD Inst Salud Carlos I, Parc Tauli 1, Barcelona 08208, Spain
Ginard, D:
Hosp Univ Son Espases, Dept Gastroenterol, Palma De Mallorca 07120, Spain
Alonso-Abreu, I:
Hosp Univ Canarias HUC, Dept Gastroenterol, Santa Cruz De Tenerife 38320, Spain
Fernandez-Salazar, L:
Hosp Clin Univ Valladolid, Dept Gastroenterol, Valladolid 47003, Spain
Trastoy, P:
Hosp Cabuenes, Dept Gastroenterol, Gijon 33394, Spain
Rivero, M:
Hosp Univ Marques de Valdecilla, Dept Gastroenterol, Santander 39008, Spain
IDIVAL, Santander 39008, Spain
Vera-Mendoza, I:
Hosp Univ Puerta de Hierro Majadahonda, Dept Gastroenterol, Madrid 28222, Spain
Vega, P:
Complexo Hosp Univ Ourense, Dept Gastroenterol, Orense 32005, Spain
Navarro, P:
Univ Valencia, Hosp Clin Univ Valencia, Dept Gastroenterol, Valencia 46010, Spain
Sierra, M:
Complejo Asistencial Univ Leon, Dept Gastroenterol, Leon 24001, Spain
Cabriada, J:
Hosp Galdakao Usansolo, Dept Gastroenterol, Galdakao 48960, Vizcaya, Spain
Aguas, M:
Hosp Univ & Politecn La Fe, Dept Gastroenterol, Valencia 46026, Spain
CIBERehd, Valencia 46026, Spain
Vicente, R:
Hosp Univ Miguel Servet, Dept Gastroenterol, Zaragoza 50009, Spain
Navarro-Llavat, M:
Hosp St Joan Despi Moises Broggi, Dept Gastroenterol, Barcelona 08970, Spain
Echarri, A:
Complejo Hosp Univ Ferrol, Dept Gastroenterol, La Coruna 15405, Spain
Gomollon, F:
Hosp Clin Univ Lozano Blesa, Dept Gastroenterol, IIS Aragon, Zaragoza 50009, Spain
CIBERehd, Zaragoza 50009, Spain
del Rio, E:
Hosp Univ Gran Canaria Dr Negrin, Dept Gastroenterol, Las Palmas Gran Canaria 35010, Spain
Pinero, C:
Hosp Univ Salamanca, Dept Gastroenterol, Salamanca 37007, Spain
Casanova, M:
Univ Autonoma Madrid, Hosp Univ La Princesa, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Inst Invest Sanitaria La Princesa IIS IP, Madrid 28006, Spain
Spicakova, K:
Hosp Univ Araba, Dept Gastroenterol, Sede Txagorritxu, Alava 01009, Spain
Hosp Univ Araba, Dept Gastroenterol, Sede Santiago, Alava 01009, Spain
de Zarate, J:
Hosp Univ Basurto, Dept Gastroenterol, Bilbao 48013, Spain
Cortes, E:
Hosp Gen Univ JM Morales Meseguer, Dept Gastroenterol, Murcia 30008, Spain
Gutierrez, A:
Hosp Gen Univ Alicante, Dept Gastroenterol, Alicante 03010, Spain
CIBERehd, Alicante 03010, Spain
Alonso-Galan, H:
Hosp Univ Donostia Donostia Unibertsitate Ospital, Dept Gastroenterol, Guipuzkoa, Spain
Clin Santa Maria de la Asuncion, Org Sanitaria Integrada Tolosaldea, Guipuzcoa 20014, Spain
Hernandez-Martinez, A:
Complejo Hosp Especialidades Torrecardenas, Dept Gastroenterol, Almeria 04009, Spain
Marrero, J:
Hosp Univ Insular Gran Canaria, Dept Gastroenterol, Las Palmas Gran Canaria 35016, Spain
Poyatos, R:
Hosp Gen Univ Ciudad Real, Dept Gastroenterol, Ciudad Real 13005, Spain
Calafat, M:
Hosp Son Llatzer, Dept Gastroenterol, Palma De Mallorca 07198, Spain
:
Hosp Francesc De Borja Gandia, Dept Gastroenterol, Valencia 46702, Spain
Robledo, P:
Hosp Univ Caceres, Dept Gastroenterol, Caceres 10004, Spain
Bosch, O:
Hosp Univ Fdn Jimenez Diaz, Dept Gastroenterol, Madrid 28040, Spain
:
Hosp Gen Univ Elche, Dept Gastroenterol, Alicante 03203, Spain
Comas, M:
Hosp Univ Mutua Terrasa, Dept Gastroenterol, Terrassa 08221, Spain
Duque, J:
Hosp San Agustin, Dept Gastroenterol, Aviles 33401, Spain
Coronel, A:
Hosp Virgen de La Concha, Dept Gastroenterol, Complejo Asistencial Zamora, Zamora 49022, Spain
Sampedro, M:
Hosp Mataro, Dept Gastroenterol, CSDM, Barcelona 08304, Spain
Abizanda, E:
Hosp Arnau Vilanova, Dept Gastroenterol, Lerida 25198, Spain
:
Hosp Villajoyosa, Dept Gastroenterol, Alicante 03570, Spain
Pozzati, L:
Hosp Merida, Dept Gastroenterol, Merida 06800, Spain
Rosaenz, H:
Hosp San Pedro, Dept Gastroenterol, Logrono 26006, Spain
Suarez, B:
Hosp Costa EOXI Lugo Cervo Monforte, Dept Gastroenterol, Lugo 27880, Spain
Serrano, P:
Hosp Univ Fdn Alcorcon, Dept Gastroenterol, Madrid 28922, Spain
Lucendo, A:
Hosp Gen Tomelloso, Dept Gastroenterol, Tomelloso 13700, Spain
Inst Invest Sanitaria Princesa IIS IP, Madrid 28006, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28006, Spain
:
Hosp Gen Univ Castellon, Dept Gastroenterol, Castellon de La Plana 12004, Spain
Bermejo, F:
Hosp Univ Fuenlabrada, Dept Gastroenterol, Madrid 28942, Spain
Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid 28942, Spain
:
Hosp Lluis Alcanyis, Dept Gastroenterol, Valencia 46800, Spain
Menacho, M:
Hosp Joan 23, Dept Gastroenterol, Tarragona 43005, Spain
Carmona, A:
Hosp Povisa, Dept Gastroenterol, Pontevedra 36211, Spain
Camargo, R:
Complejo Hosp Especialidades Virgen de la Victori, Dept Gastroenterol, Malaga 29010, Spain
Alsina, S:
Parc Sanitari St Joan de Deu, Dept Gastroenterol, Barcelona 08830, Spain
Maroto, N:
Hosp Manises, Dept Gastroenterol, Valencia 46940, Spain
de la Puerta, J:
Hosp Royo Villanova, Dept Gastroenterol, Zaragoza 50015, Spain
Castro, E:
Complexo Hosp Univ Xeral Calde Lugo, Dept Gastroenterol, Lugo 27004, Spain
Marin-Jimenez, I:
Hosp Gen Univ Gregorio Maranon, Inst Invest Biomed Gregorio Maranon IiSGM, Dept Gastroenterol, Madrid 28007, Spain
Botella, B:
Hosp Univ Infanta Cristina, Dept Gastroenterol, Madrid 28981, Spain
Sapina, A:
Hosp Manacor, Dept Gastroenterol, Manacor 07500, Spain
Cruz, N:
Hosp Doctor Jose Molina Orosa, Dept Gastroenterol, Lanzarote 35500, Spain
Forcelledo, J:
Hosp Comarcal Sierrallana, Dept Gastroenterol, Torrelavega 39300, Spain
Bouhmidi, A:
Hosp Santa Barbara, Dept Gastroenterol, Puertollano 13500, Spain
Castano-Milla, C:
Hosp Rey Juan Carlos, Dept Gastroenterol, Madrid 28933, Spain
Opio, V:
Hosp Univ Getafe, Dept Gastroenterol, Madrid 28905, Spain
Nicolas, I:
Hosp Gen Univ Reina Sofia, Dept Gastroenterol, Murcia 30003, Spain
Kutz, M:
Hosp Reina Sofia, Dept Gastroenterol, Tudela 31500, Spain
Bechiarelli, A:
Hosp Puerta del Mar, Dept Gastroenterol, Cadiz 11009, Spain
Gordillo, J:
Hosp Santa Creu & Sant Pau, Dept Gastroenterol, Barcelona 08041, Spain
Ber, Y:
Hosp San Jorge, Dept Gastroenterol, Huesca 22004, Spain
Dominguez, Y:
Hosp San Juan de Dios del Aljarafe, Dept Gastroenterol, Seville 41930, Spain
Duran, M:
Hosp Can Misses, Dept Gastroenterol, Ibiza 07800, Spain
Mondejar, S:
Hosp St Joan de Deu, Dept Gastroenterol, Barcelona 08950, Spain
Martinez-Cerezo, F:
Hosp Univ St Joan, Dept Gastroenterol, Lerida 25001, Spain
Kolle, L:
Hosp Gen La Palma, Dept Gastroenterol, Santa Cruz De Tenerife 38713, Spain
Sabat, M:
Hosp Santa Caterina, Dept Gastroenterol, Girona 17190, Spain
Ledezma, C:
Hosp Palamos, Dept Gastroenterol, Girona 17230, Spain
Iyo, E:
Hosp Comarcal Inca, Dept Gastroenterol, Inca 07300, Spain
Roncero, O:
Hosp Gen La Mancha Ctr, Dept Gastroenterol, Ciudad Real 13600, Spain
Irisarri, R:
Hosp Garcia Orcoyen, Dept Gastroenterol, Estella 31200, Spain
Lluis, L:
Hosp Sagrat Cor, Dept Gastroenterol, Barcelona 08029, Spain
Gomez, I:
Hosp Torrejon, Dept Gastroenterol, Madrid 28850, Spain
Zapata, E:
Hosp Mendaro, Dept Gastroenterol, Guipuzkoa 20850, Spain
Alcala, M:
Hosp Obispo Polanco, Dept Gastroenterol, Teruel 44002, Spain
Pascual, C:
Hosp Gen Univ Los Arcos del Mar Menor, Dept Gastroenterol, Murcia 30739, Spain
Montealegre, M:
Hosp Gen Villarobledo, Dept Gastroenterol, Albacete 02600, Spain
Mata, L:
Hosp Medina del Campo, Dept Gastroenterol, Valladolid 47400, Spain
Monrobel, A:
Hosp Montilla, Dept Gastroenterol, Cordoba 14550, Spain
Camba, A:
Hosp Quiron Costa Adeje, Dept Gastroenterol, Santa Cruz De Tenerife 38660, Spain
Hernandez, L:
Hosp Santos Reyes, Dept Gastroenterol, Aranda De Duero 09400, Spain
Tejada, M:
Clin Astarte, Dept Gastroenterol, Cadiz 11011, Spain
Mir, A:
Hosp Ernest Lluch, Dept Gastroenterol, Zaragoza 50299, Spain
Galve, M:
Hosp Cent La Cruz Roja San Jose & Santa Adela, Dept Gastroenterol, Madrid 28003, Spain
Soler, M:
Hosp San Juan Dios, Dept Gastroenterol, Tenerife 38009, Spain
Hervias, D:
Hosp Virgen de Altagracia, Dept Gastroenterol, Manzanares 13002, Spain
Gomez-Valero, J:
Hosp Dexeus, Dept Gastroenterol, Barcelona 08028, Spain
Barreiro-de Acosta, M:
Complexo Hosp Univ Santiago, Dept Gastroenterol, Santiago De Compostela 15706, Spain
Rodriguez-Artalejo, F:
Univ Autonoma Madrid IdiPaz, Sch Med, Dept Prevent Med & Publ Hlth, Madrid 28029, Spain
CIBERESP, Madrid 28029, Spain
Garcia-Esquinas, E:
Univ Autonoma Madrid IdiPaz, Sch Med, Dept Prevent Med & Publ Hlth, Madrid 28029, Spain
CIBERESP, Madrid 28029, Spain
Gisbert, J:
Univ Autonoma Madrid, Hosp Univ La Princesa, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Inst Invest Sanitaria La Princesa IIS IP, Madrid 28006, Spain
Green Published, gold
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