Complete Analysis of the Epidemiological Scenario around a SARS-CoV-2 Reinfection: Previous Infection Events and Subsequent Transmission


Por: Pérez Lago L, Pérez Latorre L, Herranz M, Tejerina F, Sola-Campoy PJ, Sicilia J, Suárez-González J, Andrés-Zayas C, Chiner-Oms A, Jiménez-Serrano S, García-González N, Comas I, González-Candelas F, Martínez-Laperche C, Catalán P, Muñoz P and García de Viedma D

Publicada: 1 sep 2021 Ahead of Print: 8 sep 2021
Resumen:
The first descriptions of reinfection by SARS-CoV-2 have been recently reported. However, these studies focus exclusively on the reinfected case, without considering the epidemiological context of the event. Our objectives were to perform a complete analysis of the sequential infections and community transmission events around a SARS-CoV-2 reinfection, including the infection events preceding it, the exposure, and subsequent transmissions. Our analysis was supported by host genetics, viral whole-genome sequencing, phylogenomic viral population analysis, and refined epidemiological data obtained from interviews with the involved subjects. The reinfection involved a 53-year-old woman with asthma (Case A), with a first COVID-19 episode in April 2020 and a much more severe second episode 4-1/2 months later, with SARS-CoV-2 seroconversion in August, that required hospital admission. An extended genomic analysis allowed us to demonstrate that the strain involved in Case A's reinfection was circulating in the epidemiological context of Case A and was also transmitted subsequently from Case A to her family context. The reinfection was also supported by a phylogenetic analysis, including 348 strains from Madrid, which revealed that the strain involved in the reinfection was circulating by the time Case A suffered the second episode, August-September 2020, but absent at the time range corresponding to Case A's first episode. IMPORTANCE We present the first complete analysis of the epidemiological scenario around a reinfection by SARS-CoV-2, more severe than the first episode, including three cases preceding the reinfection, the reinfected case per se, and the subsequent transmission to another seven cases.

Filiaciones:
Pérez Lago L:
 Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain

 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

Pérez Latorre L:
 Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain

 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

Herranz M:
 Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain

 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

 CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain

Tejerina F:
 Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain

 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

Sola-Campoy PJ:
 Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain

 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

Sicilia J:
 Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain

 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

Suárez-González J:
 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

 Genomics Unit, Gregorio Marañón General University Hospital, Madrid, Spain

Andrés-Zayas C:
 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

 Genomics Unit, Gregorio Marañón General University Hospital, Madrid, Spain

:
 Instituto de Biomedicina de Valencia-CSIC, Valencia, Spain

Jiménez-Serrano S:
 Instituto de Biomedicina de Valencia-CSIC, Valencia, Spain

:
 Joint Research Unit Infection and Public Health FISABIO-University of Valencia, Institute for Integrative Systems Biology (I2SysBio), Valencia, Spain

:
 Instituto de Biomedicina de Valencia-CSIC, Valencia, Spain

 CIBER Salud Pública (CIBERESP), Madrid, Spain

:
 Joint Research Unit Infection and Public Health FISABIO-University of Valencia, Institute for Integrative Systems Biology (I2SysBio), Valencia, Spain

 CIBER Salud Pública (CIBERESP), Madrid, Spain

Martínez-Laperche C:
 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

 Servicio de Oncohematología, Gregorio Marañón General University Hospital, Madrid, Spain

Catalán P:
 Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain

 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

 CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain

Muñoz P:
 Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain

 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

 CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain

 Departamento de Medicina, Universidad Complutense, Madrid, Spain

García de Viedma D:
 Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain

 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain

 CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain
ISSN: 23795042





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Editorial
AMER SOC MICROBIOLOGY, 1752 N ST NW, WASHINGTON, DC 20036-2904 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 6 Número: 5
Páginas:
WOS Id: 000712323600014
ID de PubMed: 34494886
imagen gold, Green Published

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