Characterization and Prediction of the Clinical Outcome of Intense Pulsed Light-Based Treatment in Dry Eye Associated to Meibomian Gland Dysfunction
Por:
Iradier MT, Del Buey MÁ, Peris-Martínez C, Cedano P and Piñero DP
Publicada:
1 ago 2021
Ahead of Print:
13 ago 2021
Categoría:
Medicine (miscellaneous)
Resumen:
This non-comparative prospective case series was conducted to characterize the clinical impact of intense pulsed light (IPL)-based treatment in dry eyes associated to Meibomian gland dysfunction (MGD), defining the predicting factors for a successful outcome with this therapy in a large case series. A total of 390 eyes (195 patients, range: 23-93 years) received four sessions of Optima IPL system (Lumenis, Yokneam, Israel). Significant changes were observed in tear film osmolarity in both eyes (p < 0.001) and in meibum quality (p < 0.001), with more eyes showing clear or yellow secretions after therapy. Mean change in the ocular surface disease index (OSDI) was -8.61, ranging from -27.00 to 11.00. This change was significantly correlated with the baseline value of OSDI (r = -0.489, p < 0.001). The change in osmolarity correlated significantly with the baseline osmolarity in both eyes (right r = -0.636, left r = -0.620, p < 0.001). A linear predicting model of the change in OSDI with therapy was obtained: change OSDI = 10.99 - 0.35 x OSDI - 1.03 x NIBUTRE-LE (mean non-invasive break up time of right and left eye) - 2.03 x Meibum quality grade (p = 0.001; R-2: 0.325). In conclusion, the improvement in symptomatology achieved with an IPL-based therapy can be predicted at baseline using a linear model considering the level of MGD and the magnitude of OSDI and NIBUT (non-invasive break-up time).
Filiaciones:
Iradier MT:
Iradier Eye Clinic, 28035 Madrid, Spain
Del Buey MÁ:
Department of Ophthalmology, Hospital Clínico Universitario "Lozano Blesa", 50009 Zaragoza, Spain
:
Cornea and External Diseases Unit, FISABIO-Oftalmología Médica (FOM), 46015 Valencia, Spain
Clínica Oftalmológica Aviñó & Peris, 46001 Valencia, Spain
Cedano P:
Iradier Eye Clinic, 28035 Madrid, Spain
:
Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 San Vicente del Rapeig, Spain
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