Clear Cell Proliferations of the Skin: A Histopathologic Review
Por:
Zaballos P, Lara-Valencia P, Van Den Bossche K, Sánchez-Martínez E, Roca-Gines J, Vila BG and Requena L
Publicada:
1 sep 2021
Resumen:
Cutaneous clear cell proliferations encompass a heterogenous group of several primary cutaneous neoplasms and metastatic tumors with different histogenesis. Many of these clear cell proliferations may seem strikingly similar under the microscope resulting in challenging diagnosis. In many of these clear cell lesions, the reason for the clear or pale appearance of proliferating cells is unknown, whereas in other ones, this clear cell appearance is due to intracytoplasmic accumulation of glycogen, mucin, or lipid. Artifacts of tissue processing and degenerative phenomenon may also be responsible for the clear cell appearance of proliferating cells. Awareness of the histopathologic findings as well as histochemical and immunohistochemical techniques are crucial to the accurate diagnosis. This review details the histopathologic features of clear cell cutaneous proliferations, classifying them according their type of differentiation and paying special attention to the histopathologic differential diagnosis among them.
Filiaciones:
Zaballos P:
Associate Staff, Dermatology Department, Hospital Sant Pau i Santa Tecla, Tarragona, Spain
Lara-Valencia P:
Associate Staff, Immunology, Genetics & Pathology and Clinical Department of Pathology & Cytology, Uppsala University Hospital, Uppsala, Sweden
Van Den Bossche K:
Associate Staff, Dermpatopathology Laboratory, Ghent, Belgium
:
Resident, Dermatology Department, Hospital Universitario Doctor Peset, Valencia, Spain
Roca-Gines J:
Resident, Dermatology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain
Vila BG:
Resident, Dermatology Department, Hospital Universitario Central de Asturias, Asturias, Spain
and
Requena L:
Chairman, Dermatology Department, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain
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