Maternal Perfluoroalkyl Substances, Thyroid Hormones, and DIO Genes: A Spanish Cross-sectional Study
Por:
Sarzo B, Ballesteros V, Iñiguez C, Manzano-Salgado CB, Casas M, Llop S, Murcia M, Guxens M, Vrijheid M, Marina LS, Schettgen T, Espada M, Irizar A, Fernandez-Jimenez N, Ballester F and Lopez-Espinosa MJ
Publicada:
17 ago 2021
Ahead of Print:
1 jul 2021
Resumen:
Results of studies on perfluoroalkyl substances (PFASs) and thyroid hormones (THs) are heterogeneous, and the mechanisms underlying the action of PFASs to target THs have not been fully characterized. We examined the relation between first-trimester maternal PFAS and TH levels and the role played by polymorphisms in the iodothyronine deiodinase 1 (DIO1) and 2 (DIO2) genes in this association. Our sample comprised 919 pregnant Spanish women (recruitment = 2003-2008) with measurements of perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononanoic acid (PFNA), thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), and free thyroxine (FT4), and we genotyped for single-nucleotide polymorphisms in the DIO1 (rs2235544) and DIO2 (rs12885300) genes. We performed multivariate regression analyses between PFASs and THs and included the interaction term PFAS-genotypes in the models. PFHxS was associated with an increase in TSH (% change in outcome [95% CI] per 2-fold PFAS increase = 6.09 [-0.71, 13.4]), and PFOA and PFNA were associated with a decrease in TT3 (-7.17 [-13.5, -0.39] and -6.28 [-12.3, 0.12], respectively). We found stronger associations between PFOA, PFNA, and TT3 for DIO1-CC and DIO2-CT genotypes, although interaction p-values were not significant. In conclusion, this study found evidence of an inverse association between PFOA and TT3 levels. No clear effect modification by DIO enzyme genes was observed.
Filiaciones:
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-University Jaume I-University of Valencia, 46019 Valencia, Spain
Ballesteros V:
Andalusian Health and Environment Observatory (OSMAN), Andalusian School of Public Health, 18011 Granada, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-University Jaume I-University of Valencia, 46019 Valencia, Spain
Department of Statistics and Operational Research, University of Valencia, 46100 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Manzano-Salgado CB:
ISGlobal, 08003 Barcelona, Spain
Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain
Casas M:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
ISGlobal, 08003 Barcelona, Spain
Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-University Jaume I-University of Valencia, 46019 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-University Jaume I-University of Valencia, 46019 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Health Information Systems Analysis Service, Conselleria de Sanitat, Generalitat Valenciana, 46010 Valencia, Spain
Guxens M:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
ISGlobal, 08003 Barcelona, Spain
Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain
Vrijheid M:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
ISGlobal, 08003 Barcelona, Spain
Universitat Pompeu Fabra (UPF), 08003, Barcelona, Spain
Marina LS:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Department of Health of the Basque Government, Subdirectorate of Public Health of Gipuzkoa, 20013 Donostia-San Sebastian, Spain
Biodonostia Health Research Institute, Environmental Epidemiology and Child Development Group, 20014 Donostia-San Sebastian, Spain
Schettgen T:
Institute for Occupational, Social and Environmental Medicine, RWTH Aachen University, 52074 Aachen, Germany
Espada M:
Clinical Chemistry Unit, Public Health Laboratory of Bilbao, 8160 Bilbao, Spain
Irizar A:
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Biodonostia Health Research Institute, Environmental Epidemiology and Child Development Group, 20014 Donostia-San Sebastian, Spain
Department of Preventive Medicine and Public Health, University of the Basque Country (UPV-EHU), 20018 San Sebastian, Spain
Fernandez-Jimenez N:
Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Nursing, Biocruces-Bizkaia Health Research Institute and University of the Basque Country (UPV/EHU), 48940 Leioa, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-University Jaume I-University of Valencia, 46019 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Faculty of Nursing and Chiropody, University of Valencia, 46010 Valencia, Spain
:
Epidemiology and Environmental Health Joint Research Unit, FISABIO-University Jaume I-University of Valencia, 46019 Valencia, Spain
Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Faculty of Nursing and Chiropody, University of Valencia, 46010 Valencia, Spain
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